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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Role makrofágy produkovaného cytokinu IMPL2 v regulaci systemického metabolismu během bakteriální infekce u \kur{Drosophila melanogaster}
 VARGOVÁ, Hana
The main goal of this bachelor thesis is to verify whether ImpL2, produced by activated immune cells, is responsible for changes in systemic metabolism during the immune response during the acute phase of bacterial infection in Drosophila melanogaster. The theoretical part includes previously known information about the immune system of mammals and D. melanogaster, especially about polarization and cellular metabolism of macrophages, as well as knowledge about the roles of the ImpL2 gene and its mammalian homologue Igfbp7. The practical part of the bachelor thesis deals with the role of the ImpL2 gene in the induction of changes in systemic metabolism during the immune response. The effect of the cytokine IMPL2 on selected metabolic genes in adipose tissue after Streptococcus pneumoniae infection was tested by means of macrophage-specific RNA interference. The work also clarifies whether this signaling factor has an effect on the concentration of selected metabolites in circulation and in macrophages during the acute phase of bacterial infection.
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Role genu \kur{Impl2} v regulaci imunitní odpovědi na bakteriální infekci u \kur{Drosophila melanogaster}
 ŠOKČEVIČOVÁ, Helena
The main aim of this thesis is to investigate the role of Impl2 gene in the regulation of immune response to bacterial infection in Drosophila melanogaster. The theoretical part provides a conceptual background concerning immunity in drosophila and also it summarizes what is known about the Impl2 gene. In the practical part, the function of Impl2 gene during infection is examined, starting with the location of its production during immune response, the changes of Impl2 gene amount during infection and its essentiality for a proper immune response. Furthermore, it examines the metabolic changes underlying an immune activation in connection to Impl2 gene. Last but not least, it tests how Impl2 gene is connected with the mobilization of energy during Chill Coma Recovery assay.
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